WILMINGTON, MA — Barnes & Noble is hosting a bookfair to benefit Wilmington String Orchestra on Sunday, November 18, 2018 at their Burlington location (98 Middlesex Turnpike).Simply present the flyer below when purchasing your items and a percentage of each purchase will benefit Strings.There will be special performances by WHS Strings students from 2pm to 4pm.Can’t make the bookfair on November 18th? You can still participate by visiting http://www.BN.COM/bookfairs from November 18 to November 23 by using ID 12441929 at checkout..Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedStrings Attached To Hold Bookfair At Barnes & Noble On November 19In “Community”WILMINGTON GIVES: Barnes & Noble To Hold In-Store & Online Book Fair For Strings AttachedIn “Community”Strings Attached To Hold Bookfair At Barnes & Noble On November 20In “Community” read more
BNP chairperson Khaleda Zia has arrived at the compound of the makeshift court which is set to announce its verdict in a graft case against the former prime minister.BNP activists clashed with the law enforcers and ruling Awami League men on her way to the court.Hundreds of BNP workers and supporters joined Khaleda Zia when her motorcade was crossing Maghbazar area.The fifth special judge’s court is set to deliver its verdict in Zia Orphanage Trust case anytime today.
An ethnic Uighur man talks on the phone in front of the Id Kah Mosque in the old town of Kashgar, Xinjiang Uighur Autonomous Region. Photo: ReutersChina will step up a campaign against religious extremism in the far western region of Xinjiang on Saturday by implementing a range of measures, including prohibiting “abnormal” beards, the wearing of veils in public places and the refusal to watch state television.Hundreds of people have died in recent years in Xinjiang, home to the Muslim Uighur people, in unrest blamed by Beijing on Islamist militants and separatists, though rights groups say the violence is more a reaction to repressive Chinese policies.The government strongly denies committing any abuses in Xinjiang and insists the legal, cultural and religious rights of Uighurs, a Turkic ethnic group, are fully protected.While China officially guarantees freedom of religion, authorities have issued a series of measures in the past few years to tackle what it sees as a rise in religious extremism.New legislation, passed by Xinjiang lawmakers on Wednesday and published on the region’s official news website, widens existing rules and will come into effect on April 1.Workers in public spaces like stations and airports will be required to “dissuade” those who fully cover their bodies, including veiling their faces, from entering, and to report them to the police, the rules state.It will be banned to “reject or refuse radio, television and other public facilities and services”, marrying using religious rather than legal procedures and “using the name of Halal to meddle in the secular life of others”.“Parents should use good moral conduct to influence their children, educate them to revere science, pursue culture, uphold ethnic unity and refuse and oppose extremism,” the rules say.The document also bans not allowing children to attend regular school, not abiding by family planning policies, deliberately damaging legal documents and “abnormal growing of beards and naming of children to exaggerate religious fervour”.A number of bans on select “extremist behaviours” had previously been introduced in some places in Xinjiang, including stopping people with head scarves, veils and long beards from boarding buses in at least one city.The new rules expand the list and apply them to the whole region.While Uighurs have traditionally practiced a more relaxed form of Islam, the popularity of veils for women in particular has grown in recent years in what experts say is an expression of opposition to Chinese controls.After a period of relative calm, there has been a rise in violence in recent months in the Xinjiang’s southern Uighur heartland and a large increase in security.Chinese President Xi Jinping called for a “great wall of iron” to safeguard Xinjiang during the annual meeting of China’s parliament earlier this month. read more
As bacteria continue to develop resistance to drugs meant to kill them, one of the areas of research has been the biofilms that the bacteria build to protect themselves against attacks by the immune system. Some chemicals have been found that disrupt the biofilm building process, but what has really been needed is something that can tear the walls apart once they have been built, allowing antibacterial agents to gain easy access to the bacteria they are meant to kill. In this new effort, the researchers report that their study of the structure of such biofilms and the means by which they are built and maintained by bacteria, revealed a possible way to use enzymes that are a part of the process, to instead tear them apart.In looking at the biofilms, the researchers discovered that two enzymes PslG and PelA, which are used by the bacteria as part of wall building, serve as a means of creating sugar polymers, which serve as building blocks of a sort—but they also help prevent the buildup of chains of sugars inside the cells of the bacteria. It occurred to the researchers that because the biofilm walls also have a chained sugar component, the same enzymes might cause wall degradation.To test this idea, the researchers applied Pseudomonas aeruginosa bacteria to cultures in dishes in their lab, waited for them to build their biofilms, and then applied synthetic forms of the enzymes. The researchers report that the enzymes went to work eating the sugar in the biofilm walls, causing the walls to melt away, leaving the bacteria without their coating of protective goo.The finding by the team is just the first step in looking into the possibility of using the enzymes to treat infections in humans, of course, a lot of work will need to be done to show that they do not cause harm, though there is cause for optimism—when they were applied to infected human lung cells, the researchers could find no damage due to the enzymes. Explore further © 2016 Phys.org Journal information: Science Advances (Phys.org)—A team of researchers from the U.S. and Canada has identified two enzymes that have proven able to break down bacterial biofilms, allowing antibacterial agents to more effectively kill their targets. In their paper published in the journal Science Advances, the team describes their study of the structure of biofilms and how that led to the identification of the enzymes that are able to break them down. More information: P. Baker et al. Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms, Science Advances (2016). DOI: 10.1126/sciadv.1501632AbstractBacterial biofilms present a significant medical challenge because they are recalcitrant to current therapeutic regimes. A key component of biofilm formation in the opportunistic human pathogen Pseudomonas aeruginosa is the biosynthesis of the exopolysaccharides Pel and Psl, which are involved in the formation and maintenance of the structural biofilm scaffold and protection against antimicrobials and host defenses. Given that the glycoside hydrolases PelAh and PslGh encoded in the pel and psl biosynthetic operons, respectively, are utilized for in vivo exopolysaccharide processing, we reasoned that these would provide specificity to target P. aeruginosa biofilms. Evaluating these enzymes as potential therapeutics, we demonstrate that these glycoside hydrolases selectively target and degrade the exopolysaccharide component of the biofilm matrix. PelAh and PslGh inhibit biofilm formation over a 24-hour period with a half maximal effective concentration (EC50) of 69.3 ± 1.2 and 4.1 ± 1.1 nM, respectively, and are capable of disrupting preexisting biofilms in 1 hour with EC50 of 35.7 ± 1.1 and 12.9 ± 1.1 nM, respectively. This treatment was effective against clinical and environmental P. aeruginosa isolates and reduced biofilm biomass by 58 to 94%. These noncytotoxic enzymes potentiated antibiotics because the addition of either enzyme to a sublethal concentration of colistin reduced viable bacterial counts by 2.5 orders of magnitude when used either prophylactically or on established 24-hour biofilms. In addition, PelAh was able to increase neutrophil killing by ~50%. This work illustrates the feasibility and benefits of using bacterial exopolysaccharide biosynthetic glycoside hydrolases to develop novel antibiofilm therapeutics. Gram-stained P. aeruginosa bacteria (pink-red rods) Credit: Wikipedia Citation: Enzymes found that can tear down bacterial biofilm walls (2016, May 23) retrieved 18 August 2019 from https://phys.org/news/2016-05-enzymes-bacterial-biofilm-walls.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Pitt-developed drug works against ‘superbug’ biofilms and respiratory virus read more